Matt Ridley is the author of provocative books on evolution, genetics and society. His books have sold over a million copies, been translated into thirty languages, and have won several awards.
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My article for The Spectator:
In the genetic diaspora of an epidemic, there is ferocious competition between strains of virus to get to the next victim first. That leads to apparently purposeful outcomes, as if the virus had a mind. One of the things people find hardest to grasp about evolution is that it appears purposeful but the mutations on which it feeds are random. How come dolphins evolved to swim if all they had to work with were random changes in genes? Viruses also mutate at random — but most people talk as though the rise and fall of these mutant versions is mainly down to chance or luck. It’s not.
Mutations occur all the time in RNA viruses; what matters is which ones find favour in natural selection. The champions of ‘Darwinian medicine’ have been calling for their colleagues to take evolution and adaptation more into account for years, and one of them, Paul Ewald of the University of Louisville, has something very relevant to say about this pandemic. Years ago, Ewald came up with a theory of why some diseases are lethal and others are mild. He argues it is all about the mode of transmission. Infections that you catch from coughs and sneezes are mostly mild; we get more than 200 different kinds of common cold virus and on the whole none of them puts you in bed, let alone kills you. Yet insect-borne diseases such as malaria, plague and yellow fever, and water-borne diseases such as cholera and typhoid, seem quite content to kill you.
My article for Spectator:
Almost 60 years ago, in February 1961, two teams of scientists stumbled on a discovery at the same time. Sydney Brenner in Cambridge and Jim Watson at Harvard independently spotted that genes send short-lived RNA copies of themselves to little machines called ribosomes where they are translated into proteins. ‘Sydney got most of the credit, but I don’t mind,’ Watson sighed last week when I asked him about it. They had solved a puzzle that had held up genetics for almost a decade. The short-lived copies came to be called messenger RNAs — mRNAs – and suddenly they now promise a spectacular revolution in medicine.
The first Covid-19 vaccine given to British people this month is not just a welcome breakthrough against a grim little enemy that has defied every other weapon we have tried, from handwashing to remdesivir and lockdowns. It is also the harbinger of a new approach to medicine altogether. Synthetic messengers that reprogram our cells to mount an immune response to almost any invader, including perhaps cancer, can now be rapidly and cheaply made.
Ever since Giacomo Pylarini, a physician working in the Ottoman Empire, sent a report to the Royal Society in 1701 that Turkish women believed pus from a smallpox survivor could induce immunity in a healthy person – and was dismissed as a dangerous quack – inoculation has been as much an art as a science. But it has proven to be the greatest life-saver of all time, eliminating smallpox and suppressing many other diseases. In Pylarini’s prescient words, it is 'an operation invented not by persons conversant in philosophy or skilled in physic, but by a vulgar, illiterate people; an operation in the highest degree beneficial to the human race.'
It looks like a vaccine is probably going to work against Covid. That was never guaranteed: it’s been decades since scientists started seeking a vaccine for malaria and HIV, with no luck so far, and flu vaccines only last for a limited time before the virus mutates. But the announcement last week that the German firm BioNTech’s vaccine, developed in partnership with Pfizer, seems to prevent Covid infection is encouraging news. Kudos to Kate Bingham for spotting it early.
An expanded version of my article for Spectator:
It is counterintuitive but the current spread of Covid may on balance be the least worst thing that could happen now. In the absence of a vaccine, and with no real prospect of eradicating the disease, the virus spreading among younger people, mostly without hitting the vulnerable, is creating immunity that will eventually slow the epidemic. The second wave is real, but it is not like the first. It would be a mistake to tackle it with compulsory lockdowns (even if called ‘circuit breakers’), whether national or local. The cure would be worse than the disease and it won’t work anyway.
The killer came from the east in winter: fever, cough, sore throat, aching muscles, headache and sometimes death. It spread quickly to all parts of the globe, from city to city, using new transport networks. In many cities, the streets were empty and shops and schools deserted. A million died. The Russian influenza pandemic of 1889-90 may hold clues to what happens next — not least because the latest thinking is that it, too, may have been caused by a new coronavirus.
In addition to the new diseases of Sars, Mers and Covid-19, there are four other coronaviruses that infect people. They all cause common colds and are responsible for about one in five such sniffles, the rest being rhinoviruses and adenoviruses. As far as we can tell from their genes, two of these coronaviruses came from African bats (one of them bizarrely via alpacas or camels), and two from Asian rodents, one of them via cattle.
We know everything about Sars-CoV-2 and nothing about it. We can read every one of the (on average) 29,903 letters in its genome and know exactly how its 15 genes are transcribed into instructions to make which proteins. But we cannot figure out how it is spreading in enough detail to tell which parts of the lockdown of society are necessary and which are futile. Several months into the crisis we are still groping through a fog of ignorance and making mistakes. There is no such thing as ‘the science’.
This is not surprising or shameful; ignorance is the natural state of things. Every new disease is different and its epidemiology becomes clear only gradually and in retrospect. Is Covid-19 transmitted mainly by breath or by touching? Do children pass it on without getting sick? Why is it so much worse in Britain than Japan? Why are obese people especially at risk? How many people have had it? Are ventilators useless after all? Why is it not exploding in India and Africa? Will there be a second wave? We do not begin to have answers to these questions.
A striking feature of Covid-19 is how medieval our response has had to be. Quarantine was the way people fought plagues in the distant past. We know by now that it will take many months to get a vaccine, whose job is to prevent you getting the disease. But what about a cure once you have caught it: why is there no pill to take? The truth is that, advanced as medical science is, we are mostly defenceless against viruses. There is no antiviral therapy to compare with antibiotics for treating bacteria.
Arguably, virology in 2020 is where bacteriology was in the 1920s. At the time, most of the experts in that field — including Alexander Fleming and his mentor, the formidable Sir Almroth Wright (nicknamed Sir Always Wrong by his foes) — thought a chemical therapy that killed bacteria without harming the patient was a wild goose chase. Instead, they argued, theway to fight bacteria was to encourage the body’s immune system. ‘Stimulate the phagocytes!’ was the cry of Wright’s semi-fictional avatar Sir Colenso Ridgeon in George Bernard Shaw’s play The Doctor’s Dilemma (referring to white blood cells). Vaccines should be used to treat as well as prevent infections, thought Wright and Fleming. Fleming then turned this theory upside down with his discovery of penicillin in 1928.
Despite what Corbynites like to claim, Britain’s National Health Service has always relied heavily on the private sector for lots of things. The food it serves to patients is not grown on state-owned farms, nor are the pills it prescribes manufactured in state-owned factories. Yet when it comes to diagnostic tests there seems to be a reluctance to buy them in, even from other public bodies let alone from private firms. This ideological prejudice is proving costly.A new report by Matthew Lesh for the Adam Smith Institute, published today may explain the British failure compared with other countries when it comes to tackling the current pandemic by testing. On 14 March, Britain was the fifth best country for quantity of Covid-19 viral tests performed per capita. By 30 March it had fallen to 26th in the league.
The generational effect of the corona-virus is cunning and baffling. By often being so mild in the young and healthy it turns people into heedless carriers. By often being so lethal in the old and sick, it makes carriers into potential executioners of friends and neighbours.
On Sunday, lonely as a cloud, I wandered across a windswept moor in County Durham and passed a solitary sandstone rock with a small, round hollow in the top, an old penny glued to the base of the hollow. It is called the Butter Stone and it’s where, during the plague in 1665, coins were left in a pool of vinegar by the inhabitants of nearby towns and villages, to be exchanged with farmers for food. The idea was that the farmer or his customer approached the rock only when the other was at a safe distance.
My article from The Spectator:
I’m no Nostradamus, but 20 years ago when I was commissioned to write a short book about disease in the new millennium, I predicted that if a new pandemic did happen it would be a virus, not a bacterium or animal parasite, and that we would catch it from a wild animal. ‘My money is on bats,’ I wrote. We now know that the natural host and reservoir of the new coronavirus, Covid-19, is a bat, and that the virus probably got into people via a live-animal market in Wuhan.
This is not the first disease bats have given us. Rabies possibly originated in bats. So did, and does, Ebola, outbreaks of which usually trace back to people coming into contact with bat roosts in caves, trees or buildings. Marburg virus, similar to Ebola, first killed people in Germany in 1967 and is now known to be a bat virus. Since 1994 Hendra virus has occasionally jumped from Australian fruit bats into horses and rarely people, with lethal effect. Since 1998 another fruit-bat virus, Nipah, has also infected and killed people mainly in India and Bangladesh. Sars, which originated in China in 2003, is derived from bats, though possibly via civet cats. So is Mers, a similar bat-borne coronavirus that’s killed hundreds of people and camels in the Middle East since 2012.
What was Brexit for? After finally taking Britain out of the European Union, the Prime Minister can now start to give us his answer — and the opportunity in front of him is pretty clear. He could speed up, perhaps double, the rate of economic growth by unleashing innovation. After leaving the slow steaming European convoy, Britain must not chug along but go full speed ahead. That means rediscovering trial and error, serendipity and swiftness — the mechanisms by which the market finds out what the consumer wants next.
The stifling of innovation by vested interests in the corridors of Brussels has held Britain back for too long — but it is not the only reason for our sluggish innovation capacity. We can also blame creaky infrastructure, neglect of the north, a glacial-speed planning system, the temptations of a speculative property market, low research and development spending, and a chronic inability to turn good ideas into big businesses.
Let nobody tell you that the second decade of the 21st century has been a bad time. We are living through the greatest improvement in human living standards in history. Extreme poverty has fallen below 10 per cent of the world’s population for the first time. It was 60 per cent when I was born. Global inequality has been plunging as Africa and Asia experience faster economic growth than Europe and North America; child mortality has fallen to record low levels; famine virtually went extinct; malaria, polio and heart disease are all in decline.
Little of this made the news, because good news is no news. But I’ve been watching it all closely. Ever since I wrote The Rational Optimist in 2010, I’ve been faced with ‘what about…’ questions: what about the great recession, the euro crisis, Syria, Ukraine, Donald Trump? How can I possibly say that things are getting better, given all that? The answer is: because bad things happen while the world still gets better. Yet get better it does, and it has done so over the course of this decade at a rate that has astonished even starry-eyed me.
My Spectator article on a surge in medical and environmental pseudoscience:
‘The whole aim of practical politics,’ wrote H.L. Mencken, ‘is to keep the populace alarmed (and hence clamorous to be led to safety) by menacing it with an endless series of hobgoblins, all of them imaginary.’ Newspapers, politicians and pressure groups have been moving smoothly for decades from one forecast apocalypse to another (nuclear power, acid rain, the ozone layer, mad cow disease, nanotechnology, genetically modified crops, the millennium bug…) without waiting to be proved right or wrong.
My Spectator article in the Christmas edition:
Christmas Day marks the birthday of one of the most gifted human beings ever born. His brilliance was of a supernoval intensity, but he was, by all accounts, very far from pleasant company. I refer to Isaac Newton.
Would you like your next child to have the intelligence of a Newton? It may not be long before this is a consumer choice, according to an ambitious new company founded in America a few months ago. Genomic Prediction initially plans to offer people who use in-vitro fertilisation the chance to identify and avoid embryos that would be likely to develop diabetes, late-life osteoporosis, schizophrenia and dwarfism. The key is the application of smart software to gigantic databases of genomic information from the population at large so as to spot dangerous combinations of gene variants. The founders also talk of being able to predict intelligence from genes, at least to some degree.
My Spectator article on the futile numbers behind wind power:
The Global Wind Energy Council recently released its latest report, excitedly boasting that ‘the proliferation of wind energy into the global power market continues at a furious pace, after it was revealed that more than 54 gigawatts of clean renewable wind power was installed across the global market last year’.
My Spectator article on the similarity between trophy hunting in Africa and grouse shooting in Durham. Both have huge benefits for non-target species of wildlife.
The vast Bubye Valley Conservancy in southern Zimbabwe is slightly larger than County Durham, as well as much hotter and drier. Yet both contain abundant wildlife thanks almost entirely to the hunting of game. In Bubye Valley, it’s lions and buffalo that are the targets; in the Durham dales, it’s grouse. But the effect is the same — a spectacular boost to other wildlife, privately funded.
My Spectator article on what it would be like for the United States to join the American Union:
o the US Secretary of State, John Kerry, thinks his country has a ‘profound interest… in a very strong United Kingdom staying in a strong EU’, and President Obama is planning to join in campaigning for the Remainders too. They say this not because they think it is good for us, but because it is in their interests that we influence Europe in a free-trading, Atlanticist direction.
Well, two can play at that game. How would Americans like it if we argued that it is in our interests that the United States should forthwith be united with all the countries in their continent north of the Panama Canal — Canada, Mexico, Guatemala, Nicaragua, Costa Rica, Belize, Honduras, El Salvador and Panama — into a vast customs union governed by a trans-national, unelected civil service. Let’s call it the American Union, or AU.
I have written five articles on climate change science and policy in the past week, for Scientific American, The Times (twice), the Wall Street Journal and the Spectator. They follow here in the form of a lengthy essay. Sentences in square brackets have been added back in after being edited out when the pieces were shortened for publication.
First, on the science - from Scientific American:
My Spectator article on meeting the man who invented vaping, Hon Lik.
Few people have heard of Hon Lik, which is a pity because he’s probably saved more lives already than anybody else I have met. Twelve years ago, he invented vaping — the idea of getting nicotine vapour from an electronic device rather than a miniature bonfire between your lips. Vaping is driving smoking out at an extraordinary rate, promising to achieve what decades of public health measures have largely failed to do. And it is doing so without official encouragement, indeed with some official resistance.
My recent Spectator diary:
Martin Williams, former head of the government’s air quality science unit, has declared that the reason we have a problem with air pollution now is that ‘policy has been focused on climate change, and reducing CO2 emissions, to the exclusion of much else, for most of the past two decades. Diesel was seen as a good thing because it produces less CO2, so we gave people incentives to buy diesel cars.’ Yet another example of how the global warming obsession has been bad for the environment — like subsidising biofuels, which encourage cutting down rainforests; or windfarms, which kill eagles and spoil landscapes; or denying coal-fired electricity to Africa, where millions die each year from the effects of cooking over smoky wood fires.
Greens are too hard on coal. If much of the world had not switched from wood to coal in the 1800s, we would have deforested the planet almost entirely. By 1860, Britain was getting as much energy from coal as a forest the size of Scotland could yield; today, we’d need a forest the size of South Africa. And coal produces less carbon dioxide than wood per unit of energy. I would say this, wouldn’t I? My ancestors were in coal from about 1700 and I still am, hosting a temporary surface mine on my land. It provides good jobs, lots of tax, a community benefits fund and an income windfall for local residents as well as me. Plus opportunities for spectacular restoration schemes, like Northumberlandia (look it up). It also helps keep electricity affordable.
To the nearest whole number, the percentage of the world's energy that comes from wind turbines today is: zero. Despite the regressive subsidy (pushing pensioners into fuel poverty while improving the wine cellars of grand estates), despite tearing rural communities apart, killing jobs, despoiling views, erecting pylons, felling forests, killing bats and eagles, causing industrial accidents, clogging motorways, polluting lakes in Inner Mongolia with the toxic and radioactive tailings from refining neodymium, a ton of which is in the average turbine - despite all this, the total energy generated each day by wind has yet to reach half a per cent worldwide.
If wind power was going to work, it would have done so by now. The people of Britain see this quite clearly, though politicians are often wilfully deaf. The good news though is that if you look closely, you can see David Cameron's government coming to its senses about the whole fiasco. The biggest investors in offshore wind - Mitsubishi, Gamesa and Siemens - are starting to worry that the government's heart is not in wind energy any more. Vestas, which has plans for a factory in Kent, wants reassurance from the Prime Minister that there is the political will to put up turbines before it builds its factory.
This forces a decision from Cameron - will he reassure the turbine magnates that he plans to keep subsidising wind energy, or will he retreat? The political wind has certainly changed direction. George Osborne is dead set against wind farms, because it has become all too clear to him how much they cost. The Chancellor's team quietly encouraged MPs to sign a letter to No. 10 a few weeks ago saying that 'in these financially straitened times, we think it is unwise to make consumers pay, through taxpayer subsidy, for inefficient and intermittent energy production that typifies onshore wind turbines'.
Here's an article I wrote for this week's Spectator about UK energy policy. Wind must give way to gas before it ruins us all, and our landscapes.
Which would you rather have in the view from your house? A thing about the size of a domestic garage, or eight towers twice the height of Nelson's column with blades noisily thrumming the air. The energy they can produce over ten years is similar: eight wind turbines of 2.5-megawatts (working at roughly 25% capacity) roughly equal the output of an average Pennsylvania shale gas well (converted to electricity at 50% efficiency) in its first ten years.
Difficult choice? Let's make it easier. The gas well can be hidden in a hollow, behind a hedge. The eight wind turbines must be on top of hills, because that is where the wind blows, visible for up to 40 miles. And they require the construction of new pylons marching to the towns; the gas well is connected by an underground pipe.
Here is a piece I just published in the Spectator.
I wrote this week's Spectator diary (no link yet):
A day in London for the launch of my new report `The Shale Gas Shock', published by the Global Warming Policy Foundation. I argue that shale gas calls the bluff of the renewable energy movement in the same way that genetically modified crops called the bluff of the organic farming movement. Just as GM allows the organic dream of drastic cuts in pesticide use to come true without high cost, so shale gas promises gradually to displace both coal (in electricity generation) and oil (in transport), drastically cutting carbon emissions without needing subsidy. Since subsidy is the lifeblood of most of the busybodies in the energy business, and since good news is no news, few people turned up for my report's launch. Back in the north, watching Newcastle United unconvincingly defeat Birmingham at St James's Park, I tried to explain `Blaydon Races' to my wife's Swedish cousin. Tyneside's national anthem chronicles no climactic battle, doomed love affair, prolonged feud or heroic feat, but the crash of a horse-drawn bus when a wheel fell off. Bizarrely, the crash never even happened, let alone on the date mentioned in the second line, 9th June 1862 - four days after the song was first performed by the song's writer, Geordie Ridley (no relation). Apparently the only bit that came true, in a verse added after the event, is the line (in Ridley's spelling) `The rain it poor'd aw the day an' myed the groons quite muddy'. By last weekend, it had not done that for weeks. I realised the drought was getting to me when I dreamed about rain. For weeks we have stared at the sky, and the web page of the Met Office rainfall radar, in the hope of a smudge that might presage a deluge. But still the sun shone every dawn, promising (in the Sarah Miles' character's words from the film White Mischief) ``another ****ing beautiful day''. The barley is beginning to suffer, though it is not yet at the point of no return. A friend says in Iowa snow and frost has delayed the maize planting to the point where it is almost too late. This is weather, not climate: noise, not signal. Just like last December's cold, or Alabama's tornadoes, or Queensland's floods, things are well within the pattern of normal variation. The global average temperature in April was 0.12 of a degree above the long term average, according to satellites: after 30 years of supposedly worrying warming. Not that this will stop the climate preachers claiming the drought as evidence of Gaia trampling out her grapes of wrath. Watch for the have-it-both-ways words: `while no single event can be blamed on climate change, this is the sort of weather we can expect more of.' The barley is grown on contract for Famous Grouse whisky. Apparently, because there is not enough winter barley in Scotland these days, they have had to redefine Scotland to Hadrian's old border, the wall, and we are north of that. Can we vote in Scotland's independence referendum, then? Driving along the military road, atop Hadrian's wall, on another ****ing beautiful evening, I ponder a simple question: did it work? We keep telling ourselves it was an act of visionary genius to build an eighty-mile whinstone border fence with watchtowers, but maybe it was just a bureaucratic folly, signed into existence by a distracted emperor with whom nobody dared argue and then found to be Maginot-useless at stopping regular barbarian incursions. Given what we know about the relentless decay into self-serving incompetence of all modern monopolies - public or private - I suspect we are too forgiving in our accounts of ancient ones, the Roman army included. As I drive, a blizzard of hawthorn flies and other insects die (dies?) on my windscreen. Judging by the Geiger-counter noise they make, it must be hundreds a minute. And there are millions of cars on the roads. Say ten billion deaths a day in Britain alone. Does this worry Jain or Buddhist drivers, who don't like killing living things? I google (actually Bing) the question and immediately find a Buddhist who advises sticking Tibetan mantras on the car so that `even if the insects get struck by the car and die, at least they touched the mantras and purify their negative karma.' A bit like papal indulgences, or carbon offsets. On Saturday night, the rain came.
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